Table 5.
LncRNAs and circRNAs in MNA NB.
| Non-Coding RNA | Expression in MNA NB | Associated Function | Citation |
|---|---|---|---|
| ncRAN | Upregulated | Oncogenic | [137] |
| lncUSMycN | Co-amplified with MYCN | Oncogenic; upregulates MYCN mRNA expression via binding to NonO | [136] |
| SNHG1 | Upregulated | Oncogenic; downregulates miR338-3p, leading to PLK4 overexpression | [138] |
| lncNB1 | Upregulated | Upregulates E2F1 expression by binding RPL35, leading to transcription of DEPDC1B | [139] |
| NDM29 | Downregulated | Induces differentiation of MNA NB cells when overexpressed | [140] |
| T-UCRs (uc.347, uc.350, uc.279, uc.460, uc.379, uc.446 and uc.364) | Upregulated | Oncogenic; involved in proliferation, apoptosis, and differentiation | [84] |
| MYCNOS-01 | Co-amplified with MYCN | Oncogenic; regulates MYCN protein expression | [141,142] |
| MYCNOS-02 | Co-amplified with MYCN | Oncogenic; interacts with G3BP1 and recruits CTCF to the MYCN promoter, thereby increasing MYCN expression. Suppresses differentiation and increases growth, invasion, and metastasis of NB cells | [141] |
| circ_0003287, circ_0008083, circ_0052767, circ_0000978, circ_0117720, chr2:15467874|15567918, circ_0008261 | Upregulated | Oncogenic | [41] |
| circARID1A | Upregulated | Oncogenic; promotes proliferation and survival of NB cells via direct interaction with KHSRP | [144] |