Figure 3:

Regulation of inflammatory markers under the influence of inflammation and cirrhosis. a) Quantified fold change of cytokine regulations under the influence of inflammation and cirrhosis in the HCCoC. Main inflammatory cytokines and chemokines were upregulated during the TME progression. b) Log2 fold change comparison between HepG2 and HepG2-CYP3A4 cell lines in HCCoC under the influence of inflammation and cirrhosis. CYP3A4 overexpressing HCCoCs secreate higher inflammatory cytokines and chemokines during the disease progression. c) Hierarchical clustering of cytokine/chemokine responses to cirrhosis and inflammation plotted in heatmaps. n = 3. All data represent means ± SD.