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. 2023 Dec 8;18(12):e0292791. doi: 10.1371/journal.pone.0292791

Fig 2. Stiffer and harder collagen fiber bundles in aged dermis.

Fig 2

(a) Representative image for quantification of mechanical properties by Nanoindentation. Total of six indents (3 from papillary, 3 from reticular dermis), as indicated by circles, per skin section were obtained. The graph represents typical load (mN) and displacement (penetration depth, nm) curve (see Methods for details). Dot lines indicate epidermal and dermal junction. Bar = 100μm. (b) Increased collagen fiber bundle stiffness in aged human skin. (c) Increased collagen fiber bundle hardness in aged human skin. Stiffness and hardness were quantified using a NanoIndenter II (Agilent Technologies, Santa Clara, CA), as described in Methods. Each group comprised six subjects. Results are expressed as the mean ± SEM.