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. 2023 Nov 28;12(23):7360. doi: 10.3390/jcm12237360

Table 4.

Poor prognostic factors of the included studies.

Authors Univariate Analysis Multivariate Analysis
Cheng et al. [15] N3 status
N ratio > 0.3
Bormann type IV
R1 resection
Lymphatic invasion
Perineural invasion
Pancreas invasion
No liver invasion
Bormann type
Curative resection
Perineural invasion
Nodal status
No liver invasion
Isozaki et al. [16] Bormann type 4
Whole stomach
Upper-third stomach
Dimension of tumor > 90 mm
>2 invaded organs
N3 status
Location of tumor
Histological depth of invasion
Jeong et al. [17] N3 status
Lympho-vascular invasion
Lymphatic invasion
Kobayasbi et al. [27] Poor differentiation
Extensive vascular invasion
Lymph vessel invasion
Peritoneal dissemination
Peritoneal dissemination
Lymph node ratio > 0.2
Poor differentiation
Min et al. [19] Bormann IV
Undifferentiated
N3 status
Pancreatic invasion
Pancreatic invasion
Mita et al. [22] N3 status
R1 resection
Organs resected >= 2
Pancreatic resection
Spleen resection
R1 resection
Pacelli et al. [8] Peritoneal resection
N + status
R + resection
N + status
Peritoneal resection
R + resection
Molina et al. [9] Lymph nodes involvement Lymphatic invasion
R1 resection
Wang et al. [20] Tumor size (>9 cm)
Advanced T stage (pT4b)
Lymph node metastasis
Advanced T stage (pT4b)
Lymph node metastasis
Yang et al. [21] Pancreas resection
Spleen resection
Resection of >15 lymph nodes
Vascular tumor emboli
R+ resection
R+ resection
Vascular tumor emboli
Lymph nodes > 15
Xiao et al. [10] Total gastrectomy
Whole gastric location
R1 resection
R1 resection
Linitis plastica
Xiao et al. [23] Tumor > 7 cm
R+ resection
Tumor > 7 cm
Non-curative resection
Ozer et al. [12] Age > 70 y
>2 organs resected
Positive lymph node metastasis
Presence of comorbidities
Age older > 70 y
Lymphatic invasion
Number of organs resected >2
Sahakyan et al. [11] Total gastrectomy
Obesity (BMI < 30)
N3 status
Obesity (BMI < 30)
Nodal stage (N3)