Figure 9.

Dose-dependent cytotoxicity on the proliferation of human breast adenocarcinoma (MCF7) Cell line (A), and non-malignant human fibroblast (HFs) cell line (B) at 5-Fu (8 µg/mL) or 5-Fu combined with various concentrations (0, 25, 50, 100, 200, and 500 µg/mL) of NPs for 24, and 48 h exposure time. Values represent the means of three replicates ± SE. IC₅₀: the half-maximal inhibitory concentration. (N.B.) significant at p ≤ 0.05, compared with negative control and 8 µg/mL free 5-Fu (positive control).