Table 3.
Associated metabolic pathways involved in ON/OP.
| Study | Pathways | Analysis Methods |
|---|---|---|
| Yin et al., 2021 [48] |
Bile secretion | Enrichment analysis of KEGG signaling pathway |
| Secondary bile acid biosynthesis | ||
| Cholesterol metabolism | ||
| Caffeine metabolism | ||
| Pyruvate metabolism | ||
| Primary bile acid biosynthesis | ||
| Li et al., 2020 [50] |
Valine, leucine, and isoleucine biosynthesis and degradation | Enrichment analysis and topology analysis |
| Aminoacyl-tRNA biosynthesis | ||
| Glycolysis or Gluconeogenesis | ||
| Glycerophospholipid metabolism | ||
| Glyoxylate and dicarboxylate metabolism | ||
| TCA cycle | ||
| Taurine and hypotaurine metabolism | ||
| Guo et al., 2022 [51] |
Tryptophan metabolism | Enrichment analysis of KEGG signaling pathway |
| Glutathione metabolism | ||
| Phospholipase D signaling pathway | ||
| Arginine, proline with alanine metabolism | ||
| Aleidi et al. 2021 [34] |
Histidine metabolism | The pathway analysis module |
| Aminoacyl-tRNA biosynthesis | ||
| Glyoxylate and dicarboxylate metabolism | ||
| Biosynthesis of unsaturated fatty acids | ||
| Deng et al., 2021 [41] |
Lipids pathways | NA |
| Cao et al., 2021 [42] |
Choline metabolism | The bubble diagram of pathway enrichment analysis |
| Glycerophospholipid metabolism | ||
| Retrograde endocannabinoid signaling | ||
| Linoleic acid metabolism | ||
| Alpha-linolenic acid metabolism | ||
| Arachidonic acid metabolism | ||
| Kou et al., 2022 [43] |
Glucose metabolism | Database searching (KEGG) and consulting relevant literature |
| Amino acids metabolism | ||
| Choline metabolism | ||
| Inflammatory response | ||
| Zhao et al., 2018 [45] |
Alanine, aspartate, and glutamate metabolism | MetaboAnalyst 3.0 software |
| Butanoate metabolism | ||
| Taurine and hypotaurine metabolism | ||
| Aminoacyl-tRNA biosynthesis | ||
| Glutathione metabolism | ||
| Primary bile acid biosynthesis | ||
| Glycine, serine, and threonine metabolism | ||
| Yu et al., 2018 [37] |
Taurine metabolism | MetaboAnalyst 3.0 software |
| β-alanine metabolism | ||
| Galactose metabolism | ||
| TCA cycle | ||
| Proparoate metabolism | ||
| Nitrogen metabolism | ||
| Butanoate metabolism | ||
| Miyamoto et al., 2018 [47] |
TCA cycle | NA |
| Urea cycle | ||
| Pentose phosphate pathway |