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. 2023 Nov 22;28(23):7707. doi: 10.3390/molecules28237707

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ferritin in health and disease. Serum ferritin has a role in health and disease. Apart from its fully described role regarding iron storage, FT also responds to inflammatory stimuli, including infection. Its rising serum levels are associated with the development of deleterious conditions, such as ferroptosis or hyperferritinemia, which makes it an attractive target for the development of new host-directed therapies. However, these increased levels also give crucial information regarding the development of certain diseases or even their progression. Additionally, due to its nanocage structure, FT has also been used as a delivery system for drug therapies, such as vaccines. Image created with BioRender (www.biorender.com, accessed on 15 September 2023).