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. 2023 Dec 8;9(49):eade1370. doi: 10.1126/sciadv.ade1370

Fig. 8. BI or its secreted products and BT differentially affect the transcriptome in stimulated human colonic epithelial cells.

Fig. 8.

(A) PCA showing gene expression profiles in human colonic epithelial cells stimulated for 6 hours with BI, BI metabolites, BI proteins, BT, or PBS. Volcano plot showing DEGs in human colonic epithelial cells stimulated under different conditions: (B) BI versus PBS. (C) BI versus BI metabolites. (D) BI versus BT. (E) BI versus BI proteins. (F) BI versus heat-killed BI. (G) Enriched pathway in BI-stimulated cells by GSEA compared to BT-stimulated cells. (H) Enriched pathway in BI-stimulated cells compared to BI metabolite–stimulated cells. Volcano plots were generated by EnhancedVolcano package with the fold change cutoff set at 1.5.