Table 5.
Non-compartmental pharmacokinetic parameters of demethyleneberberine following single i.g. (20, 40 mg/kg) and i.v. (2 mg/kg) administration in rats (mean ± SD, n = 5).
| PK Parameters | Unit | i.v. (mg/kg) | i.g. (mg/kg) | |
|---|---|---|---|---|
| 2 | 20 | 40 | ||
| AUC0–t | h·ng/mL | 111.13 ± 39.71 | 27.14 ± 2.02 | 131.60 ± 33.12 |
| AUC0–∞ | h·ng/mL | 158.75 ± 95.78 | 29.83 ± 2.14 | 133.36 ± 33.20 |
| Cmax | ng/mL | 128.24 ± 15.32 | 60.22 ± 12.53 | 308.25 ± 103.86 |
| Tmax | h | 0.08 ± 0.00 | 0.08 ± 0.00 | 0.08 ± 0.00 |
| t1/2 | h | 5.57 ± 0.83 | 4.26 ± 1.48 | 3.14 ± 0.42 |
| MRT0–∞ | h | 5.13 ± 2.91 | 4.13 ± 1.35 | 1.13 ± 0.40 |
| Bioavailability | % | - | 2.44 | 5.92 |