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. 2023 Nov 23;13(23):3004. doi: 10.3390/nano13233004

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Preparation scheme of trans-activating transcriptor (TAT) peptide-conjugated magnetic poly(D,L-lactide-co-glycolide) (PLGA)/lipid nanoparticles (MPLs) via conjugation with the TAT CPP sequence CGRKKRRQRRRK. The MPL nanoparticles combine the advantages of PLGA and magnetic liposomes for the encapsulation of the drugs hesperidin (HES), naringin (NAR), and glutathione (GSH). (b) Intracellular localization and distribution of QD-loaded fluorescein isothiocyanate (FITC)-labeled TAT-MPLs in bEnd.3 cells studied as an in vitro BBB model (reprinted with permission from the Public Library of Science, San Francisco, California, USA [105]).