Table 1.

Classification of neutropenias

Neutropenia type	Example
Acquired
Production	Cytotoxic chemotherapy, irradiation
Drugs—chloramphenicol, phenothiazines
Metabolic disease
Nutritional deficiency—vitamin B12, folate
Infectious
Viral—EBV, CMV, hepatitis, HIV, influenza Bacterial—salmonella, brucella, pertussis, rickettsia Mycobacteria Fungal
Malignant—leukemia, lymphoma myelodysplasia
Destruction	Collagen vascular disease—systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome
Drugs—penicillins, cephalosporins, quinidine sulfate
Infections
Malignant diseases—large granular lymphocyte leukemia
Sequestration	Hypersplenism
Congenital
Kostmann syndrome
Cyclic neutropenia
EBV = Epstein-Barr virus, CMV = cytomegalovirus, HIV = human immunodeficiency virus