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. 2023 Nov 23;15(23):4896. doi: 10.3390/nu15234896

Table 4.

Hazard ratios (HR) for plasma DHA and incident Alzheimer’s disease (n = 267,312).

Stratification Per Quintiles Per IQ5R
Q1
(<1.46,
Median = 1.24)
Q2
(1.46 to 1.78,
Median = 1.63)
Q3
(1.78 to 2.07,
Median = 1.92)
Q4
(2.07 to 2.47,
Median = 2.25)
Q5
(>2.47,
Median = 2.84)
All Cases/n 429/53,457 404/53,455 431/53,459 484/53,473 532/53,468 2280/267,312
HR (95% CI) 1.00 0.92 (0.80; 1.06) 0.91 (0.79; 1.04) 0.94 (0.82; 1.07) 0.93 (0.81; 1.06) 0.98 (0.89; 1.09)
Gender Men
Cases/n 267/33,633 220/27,288 205/23,521 204/20,240 195/18,143 1091/122,825
HR (95% CI) 1.00 0.96 (0.80; 1.15) 0.93 (0.78; 1.13) 0.95 (0.79; 1.15) 0.91 (0.75: 1.10) 0.92 (0.80; 1.06)
Women
Cases/n 162/19,824 184/26,167 226/29,938 280/33,233 337/35,325 1189/144,487
HR (95% CI) 1.00 0.88 (0.71; 1.10) 0.88 (0.72; 1.09) 0.92 (0.76; 1.13) 0.94 (0.77: 1.14) 1.06 (0.92; 1.12)
Age 50–59 years
Cases/n 70/18,871 43/18,288 33/17,880 34/17,213 30/16,629 210/88,881
HR (95% CI) 1.00 0.71 (0.48; 1.05) 0.58 (0.38; 0.89) * 0.65 (0.42; 1.00) * 0.59 (0.37; 0.94) * 0.62 (0.42; 0.90) *
≥60 years
Cases/n 351/20,135 360/24,461 397/22,540 445/24,457 500/27,514 2053/116,107
HR (95% CI) 1.00 0.98 (0.85; 1.14) 0.99 (0.85; 1.14) 0.99 (0.86; 1.15) 0.99 (0.85; 1.15) 1.02 (0.92; 1.13)

Note: CI = confidence interval; IQ5R, interquintile range (defined as 90th minus 10th percentiles of circulating DHA); Q = quintile. Adjusted for gender (except in gender stratification), age at enrollment (except in age stratification), APOE-ε4 carriership (non-carrier vs. carrier), education (college or above vs. high school degree or equivalent vs. less than high school vs. unknown), BMI, Townsend deprivation index, and prevalent diabetes at baseline (yes vs. no). *, p < 0.05.