Table 5.

Hazard ratios (HR) for plasma DHA and incident all-cause dementia (n = 267,312).

Stratification		Per Quintiles					Per IQ5R
		Q1 (<1.46, Median = 1.24)	Q2 (1.46 to 1.78, Median = 1.63)	Q3 (1.78 to 2.07, Median = 1.92)	Q4 (2.07 to 2.47, Median = 2.25)	Q5 (>2.47, Median = 2.84)
All	Cases/n	1065/53,457	973/53,455	992/53,459	1039/53,473	1124/53,468	5193/267,312
	HR (95% CI)	1.00	0.91 (0.83; 1.00) *	0.88 (0.81; 0.97) **	0.88 (0.80; 0.86) **	0.87 (0.79; 0.95) **	0.91 (0.86; 0.98) **
Gender	Men
	Cases/n	695/33,633	583/27,288	515/23,521	480/20,240	467/18,143	2740/122,825
	HR (95% CI)	1.00	0.98 (0.88; 1.10)	0.93 (0.82; 1.04)	0.90 (0.80; 1.01)	0.87 (0.77; 0.99) *	0.88 (0.80; 0.96) **
	Women
	Cases/n	370/19,824	390/26,167	477/29,938	559/33,233	657/35,325	2453/144,487
	HR (95% CI)	1.00	0.82 (0.71; 0.94) **	0.82 (0.72; 0.95) **	0.84 (0.73; 0.96) *	0.84 (0.73: 0.96) *	0.97 (0.88; 1.07)
Age	50–59 years
	Cases/n	175/18,871	130/18,288	104/17,880	98/17,213	94/16,629	601/88,881
	HR (95% CI)	1.00	0.87 (0.69; 1.10)	0.75 (0.58; 0.96) *	0.79 (0.61; 1.03)	0.80 (0.61; 1.05)	0.81 (0.65; 1.00) *
	≥60 years
	Cases/n	862/20,135	834/21,461	869/22,540	932/24,457	1023/27,514	4520/116,107
	HR (95% CI)	1.00	0.94 (0.85; 1.04)	0.91 (0.83; 1.00) *	0.90 (0.82; 1.00) *	0.89 (0.81; 0.98) *	0.93 (0.87; 1.00) *

Note: CI = confidence interval; IQ₅R, interquintile range (defined as 90th minus 10th percentiles of circulating DHA); Q = quintile. Adjusted for gender (except in gender stratification), age at enrollment (except in age stratification), APOE-ε4 carriership (non-carrier vs. carrier), education (college or above vs. high school degree or equivalent vs. less than high school vs. unknown), BMI, Townsend deprivation index, and prevalent diabetes at baseline (yes vs. no). *, p < 0.05; **, p < 0.01.