Table 7.
Hazard ratios (HR) for plasma non-DHA omega-3 fatty acids and incident all-cause dementia (n = 267,312).
| Stratification | Per Quintiles | Per IQ5R | |||||
|---|---|---|---|---|---|---|---|
| Q1 (<1.57, Median = 1.20) |
Q2 (1.57 to 2.08, Median = 1.84) |
Q3 (2.08 to 2.53, Median = 2.30) |
Q4 (2.53 to 3.13, Median = 2.80) |
Q5 (>3.13, Median = 3.65) |
|||
| All | Cases/n | 354/53,462 | 398/53,463 | 499/53,455 | 482/53,468 | 547/53,464 | 5193/267,312 |
| HR (95% CI) | 1.00 | 0.86 (0.78; 0.94) ** | 0.89 (0.81; 0.98) * | 0.80 (0.73; 0.88) *** | 0.79 (0.73; 0.87) *** | 0.85 (0.79; 0.91) *** | |
| Gender | Men | ||||||
| Cases/n | 574/26,087 | 537/26,133 | 598/25,751 | 517/23,986 | 514/50,868 | 2740/122,825 | |
| HR (95% CI) | 1.00 | 0.85 (0.76; 0.96) ** | 0.86 (0.76; 0.96) ** | 0.74 (0.66; 0.84) *** | 0.75 (0.66; 0.85) *** | 0.77 (0.70; 0.85) *** | |
| Women | |||||||
| Cases/n | 311/27,375 | 371/27,330 | 487/27,704 | 574/29,482 | 710/32,596 | 2453/144,487 | |
| HR (95% CI) | 1.00 | 0.86 (0.74; 1.00) * | 0.95 (0.82; 1.10) | 0.88 (0.76: 1.04) | 0.85 (0.74; 0.97) * | 0.91 (0.83; 1.01) | |
| Age | 50–59 years | ||||||
| Cases/n | 146/18,191 | 116/18,505 | 116/18,220 | 116/17,664 | 107/16,301 | 601/88,881 | |
| HR (95% CI) | 1.00 | 0.77 (0.60; 0.99) * | 0.80 (0.62; 1.02) | 0.81 (0.63; 1.05) | 0.81 (0.53; 1.05) | 0.83 (0.67; 1.03) | |
| ≥60 years | |||||||
| Cases/n | 715/16,190 | 775/19,995 | 956/23,137 | 967/26,378 | 1107/23,407 | 4520/116,107 | |
| HR (95% CI) | 1.00 | 0.87 (0.79; 0.97) ** | 0.91 (0.82; 1.00) * | 0.81 (0.73; 0.89) *** | 0.79 (0.72; 0.87) *** | 0.84 (0.78; 0.91) *** | |
Note: CI = confidence interval; IQ5R, interquintile range (defined as 90th minus 10th percentiles of circulating non-DHA omega-3); Q = quintile. Adjusted for gender (except in gender stratification), age at enrollment (except in age stratification), APOE-ε4 carriership (non-carrier vs. carrier), education (college or above vs. high school degree or equivalent vs. less than high school vs. unknown), BMI, Townsend deprivation index, and prevalent diabetes at baseline (yes vs. no). *, p < 0.05; **, p < 0.01; ***, p < 0.001.