Figure 1.

Effect of chronic DSS on mice with inducible deletion of AhR in IECs. AhR^fl/fl × Villin-Cre^ERT2 mice were injected with tamoxifen (AhR^ΔIEC) for IEC-specific deletion of AhR or the vehicle control (WT) and treated with chronic DSS. AhR deletion was confirmed by (A) mRNA levels of AhR normalized to GAPDH in the distal colon. (B) Photographs of colons after chronic DSS treatment and quantifications of (C) colon length (cm), (D) spleen/body weight and (E) colon weight/length (g/cm). Values are mean ± standard error of mean. Data were analyzed by one-way ANOVA; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.