Table 1.

(A) The categories of evidence and consensus. (B) The categories of preference.

A.Categories of evidence and consensus
Recommendations are based on level of clinical evidence available and degree of consensus
Category 1: Based upon high-level evidence, there is uniform NCCN consensus that the intervention is appropriate;
Category 2A: Based upon lower-level evidence, there is uniform NCCN consensus that the intervention is appropriate;
Category 2B: Based upon lower-level evidence, there is NCCN consensus that the intervention is appropriate;
Category 3: Based upon any level of evidence, there is major NCCN disagreement that the intervention is appropriate.
B.Categories of preference
Preferred intervention: Interventions that are based on superior efficacy, safety, and evidence, and, when appropriate, affordability.
Other recommended intervention: Other interventions that may be somewhat less efficacious, more toxic, or based on less mature data; or significantly less affordable for similar outcomes.
Useful in certain circumstances: Other interventions that may be used for selected populations (defined with recommendation).