Skip to main content
. 2023 Nov 17;21:5712–5718. doi: 10.1016/j.csbj.2023.11.028

Fig. 2.

Fig. 2

Potency of TPX-0022 against c-Met resistance-relevant mutations. (A) Potency of TPX-0022 against c-Met resistance-relevant mutations using kinase assays. (B) The positions of resistance-relevant mutations in the c-Met/TPX-0022 structure. Salt bridges are indicated as black dotted lines. (C) The modelled c-Met Y1230H/TPX-0022 complex structure was acquired by superposition of the c-Met Y1230H/compound 14 (PDB ID: 5HLW) structure with the c-Met/TPX-0022 structure. (D) The modelled c-Met Y1230C/TPX-0022 complex. The c-Met Y1230C structure was acquired by mutating H1230 to Cys on the basis of the c-Met Y1230H structure. TPX-0022 is colored yellow. c-Met WT is colored gray. c-Met Y1230H and c-Met Y1230C are colored wheat.