Table 4.
Characteristic parameters of target nodes in disease-drug-DAIs-targets network.
| Gene | Degree Centrality value | Betweenness Centrality value | Closeness Centrality value |
|---|---|---|---|
| PTGS2 | 21 | 2023.4489 | 0.2551 |
| PTGS1 | 19 | 1703.5990 | 0.2525 |
| PRKACA | 13 | 929.9431 | 0.2475 |
| PGR | 11 | 2020.4799 | 0.1997 |
| RXRA | 10 | 554.6250 | 0.2403 |
| ADRB2 | 9 | 660.2418 | 0.2380 |
| AR | 9 | 440.4197 | 0.2419 |
| ESR1 | 8 | 70.5951 | 0.1881 |
| NOS3 | 7 | 304.7564 | 0.2321 |
| CASP3 | 6 | 260.1022 | 0.2388 |
| BAX | 6 | 260.1022 | 0.2388 |
| BCL2 | 6 | 260.1022 | 0.2388 |
| NOS2 | 6 | 69.8757 | 0.2014 |
| DPP4 | 5 | 291.7130 | 0.2388 |
| PPARG | 5 | 213.7131 | 0.2335 |
| NR3C2 | 4 | 332.0284 | 0.1778 |
| AKT1 | 4 | 146.5254 | 0.2373 |
| RELA | 4 | 146.5254 | 0.2373 |
| CASP9 | 4 | 124.3405 | 0.2321 |
| ACHE | 3 | 315.3445 | 0.2278 |
| TP53 | 3 | 91.7961 | 0.2285 |
| MMP1 | 3 | 83.5120 | 0.2335 |
| TNF | 3 | 83.5120 | 0.2335 |
| AHR | 3 | 72.6011 | 0.2307 |
| PON1 | 3 | 58.5755 | 0.2251 |
| TGFB1 | 3 | 58.5755 | 0.2251 |
| PRKCA | 3 | 58.5755 | 0.2251 |
| CASP8 | 3 | 58.5755 | 0.2251 |
| GSK3B | 3 | 19.4018 | 0.1849 |
| CDK2 | 3 | 17.0759 | 0.1853 |
| SLC6A4 | 3 | 6.8894 | 0.1800 |
| PLAU | 2 | 77.2004 | 0.2258 |
| CXCL8 | 2 | 44.0750 | 0.2251 |
| CCL2 | 2 | 44.0750 | 0.2251 |
| IL6 | 2 | 44.0750 | 0.2251 |
| CDKN1A | 2 | 44.0750 | 0.2251 |
| CCND1 | 2 | 44.0750 | 0.2251 |
| IGF2 | 2 | 33.9643 | 0.2217 |
| MPO | 2 | 33.9643 | 0.2217 |
| CCNB1 | 2 | 33.9643 | 0.2217 |
| HIF1A | 2 | 33.9643 | 0.2217 |
| MMP9 | 2 | 33.9643 | 0.2217 |
| FOS | 2 | 33.9643 | 0.2217 |
| VEGFA | 2 | 33.9643 | 0.2217 |
| GSTM1 | 2 | 23.3445 | 0.2271 |
| INSR | 2 | 23.3445 | 0.2271 |
| NR1I3 | 2 | 23.3445 | 0.2271 |
| SLC2A4 | 2 | 23.3445 | 0.2271 |
| GSTP1 | 2 | 23.3445 | 0.2271 |
| NR1I2 | 2 | 23.3445 | 0.2271 |
| VCAM1 | 2 | 23.3445 | 0.2271 |
| SELE | 2 | 23.3445 | 0.2271 |
| ICAM1 | 2 | 23.3445 | 0.2271 |
| CYP1A1 | 2 | 23.3445 | 0.2271 |
| CYP1A2 | 2 | 23.3445 | 0.2271 |
| CYP3A4 | 2 | 23.3445 | 0.2271 |
| HMOX1 | 2 | 23.3445 | 0.2271 |
| STAT1 | 2 | 23.3445 | 0.2271 |
| XDH | 2 | 23.3445 | 0.2271 |
| F2 | 2 | 23.3445 | 0.2271 |
| ESR2 | 2 | 1.0910 | 0.1753 |
| KCNMA1 | 2 | 0.5000 | 0.1717 |