Table 3.
Change form baseline in hair parameters in PP dataset.
| N |
Change from baseline |
Difference between treatments |
t (p)* | Effect size |
||
|---|---|---|---|---|---|---|
| Mean (SD) | Mean (95 % CI) | Cohens ‘d' (95 % CI) | ||||
| 60 Seconds Hair Comb test | ||||||
| Hair with bulb (count) | Ashwagandha | 30 | −6.90 (1.58) | −3.77 (−4.75 to −2.79) | −7.692 (<0.0001) | −1.97 (−2.58 to −1.35) |
| Placebo | 31 | −3.13 (2.19) | ||||
| Hair without bulb (count) | Ashwagandha | 30 | −7.07 (1.68) | −3.94 (−4.92 to −2.95) | −8.010 (<0.0001) | −2.05 (−2.67 to −1.42) |
| Placebo | 31 | −3.13 (2.13) | ||||
| Trichoscan | ||||||
| Hair density (/cm2) | Ashwagandha | 30 | 7.30 (1.70) | 4.49 (3.74–5.25) | 11.952 (<0.0001) | 3.06 (2.31–3.80) |
| Placebo | 31 | 2.81 (1.19) | ||||
| Hair Growth (μm/d) | Ashwagandha | 30 | 21.76 (5.30) | 17.51 (15.40–19.61) | 16.648 (<0.0001) | 4.26 (3.34–5.17) |
| Placebo | 31 | 4.25 (2.44) | ||||
| Hair Thickness (μm) | Ashwagandha | 30 | 1.80 (0.85) | 0.90 (0.46–1.34) | 4.077 (<0.0001) | 1.04 (0.50–1.58) |
| Placebo | 31 | 0.90 (0.87) | ||||
| Anagen (%) | Ashwagandha | 30 | 3.04 (0.62) | 2.25 (1.96–2.54) | 15.483 (<0.0001) | 3.97 (3.09–4.83) |
| Placebo | 31 | 0.79 (0.51) | ||||
| Telogen (%) | Ashwagandha | 30 | −3.04 (0.62) | −2.25 (−2.54 to −1.96) | −15.483 (<0.0001) | −3.97 (−4.83 to −3.09) |
| Placebo | 31 | −0.79 (0.51) | ||||
| A:T Ratio | Ashwagandha | 30 | −2.17 (0.61) | 0.32 (−0.08 to 0.73) | 1.610 (0.113) | 0.41 (−0.10 to 0.92) |
| Placebo | 31 | −2.50 (0.93) | ||||
| Investigator's global assessment | ||||||
| Percent loss (%) | Ashwagandha | 30 | −8.50 (4.18) | −4.63 (−6.32 to −2.94) | −5.475 (<0.0001) | −1.40 (−1.96 to −0.84) |
| Placebo | 31 | −3.87 (2.13) | ||||
| Hair Pull test | ||||||
| No Hair Pulled (count) | Ashwagandha | 30 | −1.83 (0.46) | −1.12 (−1.52 to −0.73) | −5.733 (<0.0001) | −1.47 (−2.03 to −0.90) |
| Placebo | 31 | −0.71 (0.97) | ||||
| Percent Hair Pulled (%) | Ashwagandha | 30 | −8.00 (4.84) | −3.16 (−5.17 to −1.16) | −3.153 (0.003) | −0.81 (−1.33 to −0.28) |
| Placebo | 31 | −4.84 (2.73) | ||||
| Hair specific Skindex-29 | ||||||
| Symptom score | Ashwagandha | 30 | −4.07 (5.83) | −2.26 (−4.54 to 0.02) | −1.980 (0.052) | −0.51 (−1.02 to 0.01) |
| Placebo | 31 | −1.81 (2.50) | ||||
| Function score | Ashwagandha | 30 | −8.47 (10.02) | −5.47 (−9.42 to −1.51) | −2.764 (0.008) | −0.71 (−1.22 to −0.19) |
| Placebo | 31 | −3.00 (4.50) | ||||
| Emotional score | Ashwagandha | 30 | −4.80 (7.86) | −3.41 (−6.36 to −0.47) | −2.317 (0.024) | −0.59 (−1.10 to −0.08) |
| Placebo | 31 | −1.39 (2.32) | ||||
| Total score | Ashwagandha | 30 | −17.33 (22.44) | −11.14 (−19.61 to −2.67) | −2.632 (0.011) | −0.67 (−1.19 to −0.15) |
| Placebo | 31 | −6.19 (7.10) | ||||
A:T, Anagen:Telogen; CI, Confidence intervals; ITT, Intent-to-treat; PP, Per-protocol; SD, Standard deviation.