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. 2023 Nov 14;26(12):108473. doi: 10.1016/j.isci.2023.108473

Figure 1.

Figure 1

Overview of the Shortest Reactional Distance (SRD) annotation process

On the left panel, we show the main steps of the pipeline used to annotate mGWAS datasets. Boxes indicate input and outputs of processing steps described on arrows. The right panel shows the meaning of an SRD annotation of Enzyme A’s pairs within a KEGG pathway, where genes are represented as edges and metabolites as nodes. The SRD between Enzyme A and its main reactants, the substrate and the product, are of 0, everything running deeper adds 1 at each step (dashed arrows): green metabolites are at SRD = 1 and the blue metabolite is at SRD = 2 from Enzyme A.