Figure 2.

SRD of stringently associated gene-metabolite pairs in the TK study

(A) Comparison of SRD annotations for reported genome-wide significant associations from the TK study (orange) and the distribution of all SRD values within KEGG overview graph (hsa01100).

(B) Distribution of SRD values computed from permuted gene-metabolite pairs from TK study, with a median SRD of 8 (black dotted line). The median SRD of 1 (orange dotted line) represents an empirical p value of p = 0.035.

(C) Heatmap representing all genes and metabolites included in reported genome-wide significant associations from the TK study. The 40 mapped gene-metabolite associations are enclosed in black boxes on the heatmap (n = 40). Abbreviations: CoA = Coenzyme A.

∗ CoA metabolites are proxies for measured carnitines.