Fig. 2.

High glucose induces ferroptosis via various pathways, participating in the occurrence of diabetic retinopathy (DR). Partial abbreviation: TRIM46: a member of The E3 ubiquitin ligase family; GMFB: Glia maturation factor-β; ACSL4: Acyl-CoA synthetase long-chain family member 4; FABP-4: Fatty acid binding protein 4; PPARγ: Peroxisome proliferator-activated receptor γ; SLC1A5: Recombinant solute carrier family 1, member 5; CFL2: Cofilin-2; GPX4: glutathione peroxidase 4. ROS: reactive oxygen species.