Fig. 6.

Hyperinsulinaemic–euglycaemic clamps in obese male Adgrl1^VMH KD (knockdown of Adgrl1 in the VMH) mice. (a) Clamped blood glucose levels; (b) glucose infusion rate; (c) baseline and (d) clamp hepatic glucose production; (e) hepatic insulin sensitivity; (f) whole-body glucose turnover; (g) whole-body glycolysis; (h) whole-body glycogen synthesis; (i) glucose uptake in adipose tissue and (j) skeletal muscle during hyperinsulinaemic–euglycaemic clamps in the 22nd week following Adgrl1^VMH deficiency in 30-week-old male Adgrl1^VMH KD mice and their littermate controls; n=7 Ctrl and Adgrl1^VMH KD. Data are shown as mean ± SEM. Two-tailed Student’s t test: *p<0.05, **p<0.01, ***p<0.001. Ctrl, Control; HGP, hepatic glucose production