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. 2023 Dec 8;14:8125. doi: 10.1038/s41467-023-43857-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Pie chart (a) and representative examples (b) of the distribution of mouse capped peptides based on their full-length preproprotein precursors. SP, signal peptide. c H-clustered heatmap of mRNA expression for capped peptide preproprecursor home genes across mouse tissues and cell types. d Frequency of each amino acid in capped peptides versus a Uniprot reference set of known peptide hormones and neuropeptides. e, f Heatmap of amino acid frequency within four residues upstream and downstream of the N-terminal pyroglutamylation (e) or C-terminal amidation (f). c Data were obtained from BioGPS and shown as Z score of the log-transformed value. d Data are presented as mean of frequency, and p values of known peptide hormones versus capped peptides is calculated by two-sided Student’s t test. Source data are provided as a Source Data file.