Table 5.
Pathway analysis using protein biomarkers separating BPH from HC: pathways shown by number of genes identified. Pathways with 4+ associated genes and statistical significance (p-value <0.05) are shown; p-values are corrected by Bonferroni step-down.
| Term | Group FDR p-value | % Associated Genes |
|---|---|---|
| Hemostasis | 2.09E-06 | 4.8 |
| Factors involved in megakaryocyte development and platelet production | 1.88E-04 | 6.5 |
| Intrinsic Pathway of Fibrin Clot Formation | 1.12E-04 | 26.1 |
| Formation of Fibrin Clot (Clotting Cascade) | 1.12E-04 | 15.4 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 3.74E-05 | 8.8 |
| Post-translational protein phosphorylation | 3.74E-05 | 9.3 |
| Complement cascade | 1.70E-09 | 20.7 |
| Regulation of Complement cascade | 1.70E-09 | 23.4 |
| Platelet degranulation | 1.58E-05 | 10.1 |
| Platelet activation, signaling and aggregation | 1.58E-05 | 6.5 |