Table 7.
Pathway analysis using protein biomarkers segregating BPH from PCa: pathways shown by number of genes identified. Pathways with 4+ associated genes and statistical significance (p-value <0.05) are shown; p-values are corrected by Bonferroni step-down.
| Term | Group FDR p-value | % Associated Genes |
|---|---|---|
| Complement cascade | 1.06E-13 | 22.4 |
| Regulation of Complement cascade | 1.06E-13 | 23.4 |
| Common Pathway of Fibrin Clot Formation | 2.95E-06 | 27.3 |
| Formation of Fibrin Clot (Clotting Cascade) | 2.95E-06 | 20.5 |
| Platelet degranulation | 3.81E-06 | 10.1 |
| Post-translational protein phosphorylation | 2.24E-05 | 10.2 |
| MAP2K and MAPK activation | 3.87E-04 | 15.0 |
| Signaling by moderate kinase activity BRAF mutants | 3.87E-04 | 12.8 |
| Signaling by high-kinase activity BRAF mutants | 3.87E-04 | 16.7 |
| Signaling by RAS mutants | 3.87E-04 | 12.8 |
| Signaling by BRAF and RAF1 fusions | 3.87E-04 | 10.4 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.87E-04 | 12.8 |
| Platelet Aggregation (Plug Formation) | 3.87E-04 | 12.8 |
| Signaling downstream of RAS mutants | 3.87E-04 | 12.8 |
| Signaling by RAF1 mutants | 3.87E-04 | 11.6 |
| Initial triggering of complement | 2.76E-03 | 17.4 |
| Plasma lipoprotein remodeling | 3.80E-03 | 12.1 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 4.23E-03 | 10.8 |
| Interaction between L1 and Ankyrins | 4.38E-03 | 12.9 |