Table 3.
Effect of Lp.Cr on diuresis.
| Time (h) | Urine volume (ml)/100g body weight |
|||||
|---|---|---|---|---|---|---|
| Control |
Standard |
Treatment |
||||
| NS (10 ml/kg) | Furosemide (10 mg/kg) | Lp.Cr (mg/kg) |
||||
| 10 | 30 | 100 | 300 | |||
| 1 | 0.15 ± 0.07 | 0.85 ± 0.07** | 0.08 ± 0.02 | 0.24 ± 0.07 | 0.39 ± 0.06 | 0.53 ± 0.09 |
| 3 | 0.50 ± 0.09 | 1.72 ± 0.19*** | 0.68 ± 0.07 | 0.93 ± 0.06 | 0.93 ± 0.06 | 1.08 ± 0.08* |
| 5 | 0.83 ± 0.11 | 2.62 ± 0.24*** | 1.04 ± 0.11 | 1.49 ± 0.03* | 1.49 ± 0.10* | 2.51 ± 0.14*** |
| 7 | 1.33 ± 0.10 | 3.42 ± 0.29*** | 1.85 ± 0.06 | 2.16 ± 0.07** | 2.48 ± 0.26*** | 3.35 ± 0.19*** |
| 24 | 2.33 ± 0.22 | 4.88 ± 0.31*** | 2.70 ± 0.09 | 3.36 ± 0.27*** | 4.15 ± 0.28*** | 4.15 ± 0.12*** |
Results were analyzed by using two way ANOVA followed by Dunnett's multiple comparison test. All treatment groups were compared with control group and significance was denoted (*) if P < 0.05, (**) if P < 0.01 and (***) if P < 0.001.