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. 2023 Dec 8;14:8142. doi: 10.1038/s41467-023-43672-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic overview of isofalcarintriol (1a) supplementation study with C57BL/6NRj mice on high-fat diet. b Glucose tolerance test with male mice (DMSO: n = 12 mice; IFT: n = 15 mice) (15 min: p = 0.01). c Fasted blood glucose level in male mice (DMSO: n = 12 mice; IFT: n = 15 mice) upon isofalcarintriol (1a) supplementation after 16 weeks (p = 0.0022). d Glucose tolerance test with female mice (n = 14 mice per treatment) after 9 weeks of treatment (120 min: p = 0.02). e Fasted blood glucose level in female mice (DMSO: n = 14 mice; IFT: n = 13 mice) upon isofalcarintriol (1a) supplementation (p = 0.0048). f–i Mitochondrial mass (mtDNA/nDNA ratio) after supplementation of isofalcarintriol (1a) in (f) HepG2 cells (DMSO: n = 6; IFT: n = 3 independent cell samples) (p = 0.0014). g C. elegans (n = 3 biologically independent samples per condition) (10 nM: p = 0.0238), and (h) male (n = 9 mice per treatment) and (i) female (n = 8 mice per treatment) high-fat diet mouse muscle tissue (M. gastrocnemius) (p = 0.0222). j Thrashing assay quantifying motility of C. elegans on day 5 of adulthood (DMSO: n = 221; IFT = 248 nematodes in two independent experiments) (p = 0.0134). Treadmill exercise with C57BL/6NRj (k) male (DMSO: n = 10; IFT: n = 9 mice) (p = 0.07) and (l) female mice (DMSO: n = 8; IFT: n = 9 mice) (p = 0.0318) on high-fat diet. All data are represented as average + SD or ± SD. Statistics: two-sided unpaired student’s t-test; two-way repeated measures ANOVA; one-way ANOVA and Dunnett’s post-hoc test. Source data are provided as a Source Data file.