Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 8;7:131. doi: 10.1038/s41698-023-00479-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Concordance of ALLIUM subtype estimation for 67 B-other patients with both DNA methylation (DNAm, x-axis) and gene expression (GEX, y-axis) data. b ALLIUM stratification into subtype and tier group for the 154 B-other patients. c Subtype distribution after molecular and ALLIUM re-classification for the complete set of 281 patients with unclassified subtype at the start of the study. d Unsupervised dimensionality reduction (UMAP) based on the DNAm levels of 379 CpG sites across the 971 samples with molecularly defined subtype and 139 controls used to train ALLIUM DNAm and the 102 B-other samples reclassified by ALLIUM DNAm. e UMAP based on 356 genes across 248 samples with molecularly defined subtype and 12 controls used to design ALLIUM GEX and the 56 B-other samples reclassified by ALLIUM GEX. f Flow chart of molecular subtype revision in the study. g Distribution of subtypes across entire BCP-ALL cohort (n = 1025) color-coded by subtype determined at ALL diagnosis (start of study) and h distribution after molecular screening and ALLIUM re-classification (end of study).