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. 2023 Dec 7;13:21703. doi: 10.1038/s41598-023-48993-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Construction of probe sequences for computational APP gencDNA screening. We searched for the same sequence of 2 bases at the 3′ end and 2 bases at the 5′ end. A probe sequence of 30 bases was created by combining 16 bases, including 2 homologous bases at the 3′ end and 16 bases including 2 homologous bases at the 5′ end, and removing one pair of 2 homologous bases. The probe sequence's construction region was the APP gene's coding region, and homologous regions at least 10 bases apart were selected. Probe sequences with identical sequences in the APP mRNA (APP transcript variant 1, Accession number NM_000484) and duplicates were removed, resulting in a final set of 182,654 probe sequences.