Fig. 5.

Replication kinetics of viral isolates and their correlation with proinflammatory markers. (a) Cytopathic effect on Vero cells infected with CHIKV clinical isolates: Panel A shows the slow growing isolates at 0 h, 24 h, and 48 h post infection timepoint, similarly Panel B shows post infection timepoint of fast-growing isolates at 0 h, 24 h, and 48 h. (b) CHIKV clinical isolates (n = 57) growth kinetics represented by a heatmap the peak of virus titre at 24 h, 48 h, and 78 h clustered with the green bars and low titter is represented by red colour (c) Association of serum cytokine levels to the CHIKV replication kinetics. CHIKV – chikungunya virus.