Table 2. Associations of BMI and WHtR With FTO SNVs, Controlling for Sex and Psychosocial Status in Self-Identified Black Participantsa.
| FTO SNV LD block proxy | FTO | Sex | Age | Education | Income | Stress | Depression | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | |
| BMIb | ||||||||||||||
| rs1558902 | 0.272 (0.132) | .04 | −1.807 (0.121) | <.001 | −0.061 (0.007) | <.001 | −0.287 (0.064) | <.001 | 0.199 (0.072) | .006 | −0.028 (0.024) | .25 | 0.042 (0.03) | .16 |
| rs1121980 | 0.093 (0.084) | .27 | −1.805 (0.122) | <.001 | −0.061 (0.007) | <.001 | −0.287 (0.064) | <.001 | 0.199 (0.072) | .006 | −0.028 (0.024) | .25 | 0.042 (0.03) | .16 |
| rs17817449 | 0.041 (0.085) | .63 | −1.807 (0.122) | <.001 | −0.061 (0.007) | <.001 | −0.287 (0.064) | <.001 | 0.199 (0.072) | .006 | −0.028 (0.024) | .25 | 0.042 (0.03) | .17 |
| rs8050136 | 0.054 (0.084) | .52 | −1.807 (0.122) | <.001 | −0.061 (0.007) | <.001 | −0.287 (0.064) | <.001 | 0.199 (0.072) | .006 | −0.028 (0.024) | .25 | 0.042 (0.03) | .16 |
| rs9941349 | 0.222 (0.106) | .04 | −1.806 (0.122) | <.001 | −0.061 (0.007) | <.001 | −0.287 (0.064) | <.001 | 0.199 (0.072) | .006 | −0.028 (0.024) | .25 | 0.042 (0.03) | .16 |
| rs9930506 | 0.184 (0.101) | .07 | −1.807 (0.122) | <.001 | −0.061 (0.007) | <.001 | −0.287 (0.064) | <.001 | 0.199 (0.072) | .006 | −0.028 (0.024) | .25 | 0.042 (0.03) | .16 |
| WHtRc | ||||||||||||||
| rs1558902 | 0.003 (0.002) | .21 | −0.021 (0.002) | <.001 | 0.001 (<0.001) | <.001 | −0.006 (0.001) | <.001 | −0.002 (0.001) | .05 | −0.001 (<0.001) | .23 | 0.002 (<0.001) | <.001 |
| rs1121980 | 0.001 (0.002) | .38 | −0.021 (0.002) | <.001 | 0.001 (<0.001) | <.001 | −0.006 (0.001) | <.001 | −0.002 (0.001) | .05 | −0.001 (<0.001) | .23 | 0.002 (<0.001) | <.001 |
| rs17817449 | 0.001 (0.002) | .94 | −0.021 (0.002) | <.001 | 0.001 (<0.001) | <.001 | −0.006 (0.001) | <.001 | −0.002 (0.001) | .05 | −0.001 (<0.001) | .23 | 0.002 (<0.001) | <.001 |
| rs8050136 | 0.001 (0.002) | .60 | −0.021 (0.002) | <.001 | 0.001 (<0.001) | <.001 | −0.006 (0.001) | <.001 | −0.002 (0.001) | .05 | −0.001 (<0.001) | .23 | 0.002 (<0.001) | <.001 |
| rs9941349 | 0.002 (0.002) | .19 | −0.021 (0.002) | <.001 | 0.001 (<0.001) | <.001 | −0.006 (0.001) | <.001 | −0.002 (0.001) | .05 | −0.001 (<0.001) | .24 | 0.002 (<0.001) | <.001 |
| rs9930506 | 0.003 (0.002) | .06 | −0.021 (0.002) | <.001 | 0.001 (<0.001) | <.001 | −0.006 (0.001) | <.001 | −0.002 (0.001) | .05 | −0.001 (<0.001) | .23 | 0.002 (<0.001) | <.001 |
Abbreviation: BMI, body mass index; LD, linkage disequilibrium; SNV, single-nucleotide variant; WHtR, waist-to-height ratio.
a
Female was a reference group for sex, and lower education and income level was the reference group from psychosocial status. The significance level was assessed at .05.
b
General linear model: BMI = intercept + SNV (eg, LD Block 1: rs1558902: A) + sex + age + income + education + stress + depression + PC 1-10 + error.
c
General linear model: WHtR = intercept + SNV (eg, LD Block 1: rs1558902: A) + sex + age + income + education + stress + depression + PC 1-10 + error.