Table 3. Associations of BMI and WHtR With FTO SNV rs1558902, Controlling for Sex and Psychosocial Status in Self-Identified White Participants.
| FTO SNV LD block proxy | FTO | Sex | Age | Education | Income | Stress | Depression | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | |
| BMIb | ||||||||||||||
| rs1558902 | 0.536 (0.173) | .002 | 0.525 (0.256) | .04 | −0.082 (0.012) | <.001 | −0.400 (0.136) | .003 | −0.042 (0.149) | .78 | 0.007 (0.056) | .91 | 0.010 (0.067) | .88 |
| WHtRc | ||||||||||||||
| rs1558902 | 0.007 (0.003) | .02 | 0.013 (0.005) | .004 | 0.001 (<0.001) | .04 | −0.009 (0.002) | <.001 | −0.006 (0.003) | .03 | 0.001 (0.001) | .61 | 0.002 (0.001) | .07 |
Abbreviation: BMI, body mass index; LD, linkage disequilibrium; SNV, single-nucleotide variant; WHtR, waist-to-height ratio.
a
Female was a reference group for sex, and lower education and income level was the reference group from psychosocial status. The Bonferroni-correct significance level was .05.
b
General linear model: BMI = intercept + SNV (proxy LD block SNV: rs1558902) + sex + age + income + education + stress + depression + PC 1-10 + error.
c
General linear model: WHtR = intercept + SNV (proxy LD block SNV: rs1558902) + sex + age + income + education + stress + depression + PC 1-10 + error.