Table 1.
Cumulative incidence of dementias by vascular diseases in men with prostate cancer with up to 26 years of follow-up
| Characteristics | Cumulative incidence (row %) of ADRD* | ||||||
|---|---|---|---|---|---|---|---|
| AD | Vascular | DLB | FTD | MCI | Others | Total | |
| Cardiovascular disease | |||||||
| No | 9.95 | 4.50 | 1.19 | 0.23 | 2.15 | 27.25 | 29.11 |
| Yes | 10.34 | 5.47 | 0.96 | 0.20 | 1.92 | 31.65 | 33.80 |
| Stroke | |||||||
| No | 9.50 | 4.05 | 1.13 | 0.22 | 2.05 | 26.25 | 28.03 |
| Yes | 13.58 | 8.54 | 1.46 | 0.31 | 2.72 | 38.03 | 40.70 |
| Hypertension | |||||||
| No | 9.73 | 4.11 | 1.15 | 0.21 | 1.93 | 25.54 | 27.31 |
| Yes | 10.13 | 4.88 | 1.18 | 0.24 | 2.25 | 28.92 | 30.88 |
| Diabetes | |||||||
| No | 9.90 | 4.38 | 1.21 | 0.23 | 2.12 | 26.87 | 28.68 |
| Yes | 10.24 | 5.24 | 1.06 | 0.23 | 2.19 | 30.11 | 32.23 |
| Age (years) | |||||||
| 65-69 | 5.22 | 2.57 | 0.87 | 0.21 | 1.71 | 17.02 | 18.46 |
| 70-74 | 9.32 | 4.30 | 1.30 | 0.25 | 2.36 | 25.98 | 27.83 |
| 75-79 | 13.52 | 6.06 | 1.40 | 0.26 | 2.50 | 34.48 | 36.61 |
| 80-84 | 15.77 | 7.10 | 1.40 | 0.21 | 2.33 | 40.24 | 42.69 |
| 85 or older | 14.19 | 6.40 | 0.87 | 0.14 | 1.61 | 41.98 | 44.39 |
| Race/ethnicity | |||||||
| NH-Whites | 9.90 | 4.39 | 1.22 | 0.25 | 2.26 | 27.43 | 29.3 |
| NH-Blacks | 10.70 | 6.11 | 0.88 | 0.14 | 1.50 | 28.86 | 30.71 |
| NH-Asians/Pacific Islanders | 9.03 | 4.12 | 0.95 | 0.16 | 1.68 | 26.10 | 28.13 |
| Hispanics | 9.64 | 4.35 | 1.11 | 0.14 | 1.68 | 27.64 | 29.54 |
| Others | 9.98 | 5.04 | 1.07 | 0.15 | 1.87 | 29.49 | 31.58 |
| unknown/missing | 11.36 | 5.06 | 1.27 | 0.27 | 2.62 | 30.2 | 32.23 |
| Marital status | |||||||
| Married | 6.25 | 2.50 | 1.01 | 0.23 | 2.27 | 19.15 | 20.80 |
| Unmarried | 12.67 | 6.22 | 1.31 | 0.23 | 2.04 | 34.00 | 36.07 |
| Unknown | 10.42 | 4.37 | 1.10 | 0.21 | 2.11 | 27.73 | 29.61 |
| Tumor stage | |||||||
| Local/Regional | 10.18 | 4.64 | 1.24 | 0.24 | 2.26 | 27.72 | 29.60 |
| Distant | 4.46 | 2.46 | 0.30 | 0.08 | 0.75 | 20.90 | 22.24 |
| Unknown/missing | 12.60 | 6.03 | 0.96 | 0.15 | 1.61 | 33.56 | 35.99 |
| Tumor grade | |||||||
| Well-differentiated | 11.59 | 6.15 | 0.94 | 0.18 | 1.12 | 29.16 | 31.12 |
| Moderately-differentiated | 11.33 | 5.14 | 1.38 | 0.27 | 2.34 | 29.71 | 31.64 |
| Poorly-differentiated | 8.19 | 3.61 | 1.00 | 0.19 | 2.17 | 24.60 | 26.41 |
| Unknown/Missing | 9.70 | 5.09 | 0.91 | 0.18 | 1.41 | 29.88 | 31.85 |
| Chemotherapy | |||||||
| No | 9.32 | 4.36 | 1.11 | 0.23 | 2.06 | 25.58 | 27.44 |
| Yes | 11.12 | 4.97 | 1.27 | 0.23 | 2.25 | 31.19 | 33.13 |
| Radiotherapy | |||||||
| No | 10.30 | 4.84 | 1.12 | 0.21 | 1.91 | 28.63 | 30.52 |
| Yes | 9.61 | 4.30 | 1.23 | 0.24 | 2.39 | 26.50 | 28.39 |
| Androgen deprivation therapy | |||||||
| No | 9.29 | 4.33 | 1.11 | 0.23 | 2.09 | 25.68 | 27.54 |
| Yes | 11.41 | 5.12 | 1.28 | 0.23 | 2.23 | 31.74 | 33.68 |
| Comorbidity Scores | |||||||
| 0 | 9.75 | 4.36 | 1.19 | 0.23 | 2.20 | 26.08 | 27.91 |
| 1 | 10.78 | 5.10 | 1.16 | 0.23 | 2.01 | 31.41 | 33.41 |
| ≥2 | 10.21 | 5.65 | 0.94 | 0.16 | 1.77 | 34.12 | 36.31 |
| SEER Areas | |||||||
| Connecticut | 11.53 | 7.91 | 1.29 | 0.42 | 2.21 | 32.00 | 34.07 |
| Detroit | 16.77 | 8.60 | 1.56 | 0.22 | 1.96 | 38.62 | 40.83 |
| Hawaii | 12.18 | 7.03 | 0.92 | 0.16 | 2.29 | 32.25 | 34.31 |
| Iowa | 10.28 | 4.06 | 1.40 | 0.21 | 1.64 | 30.25 | 31.68 |
| New Mexico | 10.16 | 4.76 | 1.14 | 0.12 | 1.86 | 31.82 | 33.44 |
| Seattle | 5.76 | 2.86 | 0.45 | 0.11 | 1.00 | 16.29 | 17.82 |
| Utah | 9.48 | 3.64 | 0.99 | 0.17 | 1.70 | 27.83 | 29.56 |
| Georgia | 6.77 | 2.42 | 0.55 | 0.21 | 1.34 | 19.38 | 20.92 |
| Kentucky | 9.86 | 3.11 | 1.35 | 0.22 | 1.45 | 28.71 | 29.95 |
| Louisiana | 6.19 | 2.54 | 0.70 | 0.08 | 1.06 | 18.04 | 19.42 |
| New Jersey | 11.21 | 5.06 | 1.43 | 0.29 | 3.03 | 28.56 | 30.94 |
| California | 9.38 | 4.09 | 1.29 | 0.25 | 2.79 | 27.88 | 29.96 |
| Total | 9.98 | 4.59 | 1.17 | 0.23 | 2.13 | 27.65 | 29.54 |
*
ADRD (Alzheimer’s disease and related dementias), AD (Alzheimer’s disease), Vascular (vascular dementia), DLB (dementia with Lewy bodies), FTD (Frontotemporal degeneration and dementias), MCI (Mild cognitive impairment), others (other dementias), and total (any of above ADRD).