Table 5.
Adjusted hazard ratio of AD and ADRD after excluding dementia cases that occurred within 1 or 5 years, by history of vascular diseases
| Characteristics | Adjusted hazard ratio (95% CI)* of AD and ADRD** by excluding dementia cases that occurred <1 year or <5 years after the baseline | |||||
|---|---|---|---|---|---|---|
| Cases <1 year of baseline were excluded | Cases <5 years of baseline were excluded | All cases included after baseline | ||||
| AD | ADRD | AD | ADRD | AD | ADRD | |
| Cardiovascular disease (CVD) | ||||||
| CVD (Yes vs. No) | 1.11(1.07-1.15) | 1.22(1.19-1.24) | 1.08(1.03-1.14) | 1.18(1.15-1.21) | 1.09(1.06-1.14) | 1.17(1.15-1.20) |
| Myocardial infarction (Yes vs. No) | 1.12(1.07-1.17) | 1.15(1.12-1.18) | 1.12(1.06-1.18) | 1.14(1.11-1.18) | 1.11(1.06-1.16) | 1.13(1.10-1.16) |
| Congestive heart failure (Yes vs. No) | 1.08(1.01-1.15) | 1.27(1.23-1.31) | 1.02(0.94-1.11) | 1.20(1.15-1.25) | 1.06(1.00-1.12) | 1.19(1.15-1.23) |
| Peripheral vascular disease (Yes vs. No) | 0.97(0.84-1.11) | 1.25(1.16-1.34) | 0.95(0.79-1.14) | 1.18(1.08-1.29) | 0.96(0.85-1.09) | 1.16(1.08-1.24) |
| Stroke | ||||||
| Yes vs. No | 1.45(1.40-1.50) | 1.51(1.49-1.54) | 1.33(1.27-1.38) | 1.42(1.39-1.45) | 1.50(1.46-1.55) | 1.59(1.56-1.61) |
| Hypertension | ||||||
| Yes vs. No | 1.04(1.02-1.07) | 1.19(1.17-1.20) | 1.06(1.03-1.09) | 1.21(1.19-1.23) | 1.04(1.02-1.07) | 1.13(1.11-1.14) |
| Diabetes | ||||||
| Yes vs. No | 1.18(1.15-1.21) | 1.34(1.32-1.36) | 1.17(1.13-1.21) | 1.34(1.32-1.36) | 1.17(1.14-1.20) | 1.25(1.23-1.27) |
| Age (years) | ||||||
| 65-69 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 70-74 | 1.87(1.81-1.94) | 1.60(1.57-1.63) | 1.81(1.74-1.87) | 1.56(1.53-1.59) | 1.89(1.83-1.96) | 1.61(1.58-1.64) |
| 75-79 | 3.20(3.09-3.31) | 2.57(2.52-2.62) | 2.96(2.85-3.07) | 2.46(2.41-2.51) | 3.26(3.16-3.37) | 2.52(2.47-2.56) |
| 80-84 | 4.86(4.68-5.05) | 4.05(3.96-4.14) | 4.17(3.98-4.37) | 3.75(3.66-3.85) | 5.02(4.84-5.21) | 3.77(3.69-3.85) |
| 85 or older | 6.49(6.18-6.83) | 6.23(6.06-6.40) | 4.82(4.50-5.17) | 4.96(4.79-5.14) | 6.98(6.67-7.31) | 5.67(5.53-5.81) |
| Race/ethnicity | ||||||
| NH-Whites | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| NH-Blacks | 1.24(1.19-1.29) | 1.23(1.21-1.26) | 1.19(1.14-1.25) | 1.18(1.15-1.21) | 1.26(1.22-1.31) | 1.25(1.22-1.27) |
| NH-Asians/P. Islanders | 0.80(0.75-0.86) | 0.80(0.77-0.83) | 0.81(0.75-0.88) | 0.83(0.79-0.86) | 0.80(0.75-0.85) | 0.80(0.77-0.83) |
| Hispanics | 1.06(1.01-1.11) | 1.03(1.00-1.06) | 1.03(0.98-1.10) | 1.04(1.01-1.07) | 1.07(1.02-1.12) | 1.03(1.00-1.06) |
| Others | 0.83(0.74-0.92) | 0.81(0.76-0.86) | 0.79(0.70-0.89) | 0.80(0.75-0.85) | 0.82(0.74-0.91) | 0.85(0.80-0.90) |
| Unknown/missing | 0.95(0.89-1.01) | 0.92(0.88-0.95) | 0.96(0.89-1.04) | 0.95(0.91-0.99) | 0.94(0.89-1.00) | 0.92(0.89-0.96) |
| Chemotherapy | ||||||
| Yes vs. No | 1.15(1.09-1.22) | 1.25(1.21-1.29) | 1.09(1.01-1.17) | 1.22(1.18-1.27) | 1.14(1.08-1.21) | 1.16(1.13-1.20) |
| Radiotherapy | ||||||
| Yes vs. No | 0.87(0.85-0.90) | 0.89(0.87-0.90) | 0.94(0.92-0.97) | 0.95(0.93-0.96) | 0.85(0.83-0.87) | 0.87(0.86-0.88) |
| Androgen deprivation therapy | ||||||
| Yes vs. No | 0.98(0.92-1.03) | 0.90(0.88-0.93) | 0.99(0.92-1.07) | 0.89(0.85-0.92) | 0.99(0.94-1.05) | 0.98(0.95-1.01) |