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. 2023 Dec 8;21:891. doi: 10.1186/s12967-023-04524-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The 2D interaction plots of GR37 and GR41 as docked to CD19 and the predicted impact of temperature on their affinity to CD19. a and b: The 2D interaction plots of GR37 and GR41 as docked to CD19, respectively. The horizontal dashed line shows the interface between the VHH and the antigen. The interactive CD19 and VHH residues are represented above and below the dashed line, respectively. Hydrophobic contacts are indicated by arcs whose radiating spokes are directed toward the atoms they are in contact with. Also, dashed lines between atoms are representatives of hydrogen bonds. The VHH residues are presented with the “V” chain whereas CD19 is in the “A” chain. All antibody residue numberings are in accordance with the Kabat numbering scheme. c: The predicted impact of temperature on the predicted affinity of GR37 and GR41 to CD19