Table 2.
Association between PRS, lifestyles, and risk of PC
| Characteristics | PC/non-PC | Model 1a | Model 2a | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value for trend c | HR (95% CI) | P value | HR (95% CI) | P value for trend c | ||
| PRS | 1.58 (1.46–1.70) | 1.45E-32 | 1.58 (1.47–1.71) | 5.78E-33 | |||||
| Low | 217/113,308 | 0.60 (0.50–0.70) | 1.56E-09 | 0.59 (0.50–0.70) | 1.23E-09 | ||||
| Intermediate b | 364/113,207 | 1 [Reference] | NA | 1 [Reference] | NA | ||||
| High | 548/112,987 | 1.51 (1.32–1.72) | 1.31E-09 | 1.51 (1.32–1.73) | 9.96E-10 | ||||
| Weighted healthy lifestyle score | 0.67 (0.62–0.72) | 6.65E-26 | 0.69 (0.64–0.74) | 8.79E-22 | |||||
| Unfavorable | 526/112,905 | 1 [Reference] | NA | 1 [Reference] | NA | ||||
| Intermediate | 361/113,497 | 0.67 (0.59–0.77) | 6.86E-09 | 0.66 (0.58–0.76) | 2.40E-09 | ||||
| Favorable | 242/113,100 | 0.45 (0.39–0.52) | 9.36E-25 | 0.48 (0.41–0.56) | 1.69E-20 | ||||
| Unweighted healthy lifestyle score | 0.72 (0.67–0.78) | 4.30E-19 | 0.78 (0.72–0.84) | 1.63E-11 | |||||
| Unfavorable | 509/116,096 | 1 [Reference] | NA | 1 [Reference] | NA | ||||
| Intermediate | 339/101,907 | 0.75 (0.65–0.86) | 3.60E-05 | 0.81 (0.70–0.93) | 2.23E-03 | ||||
| Favorable | 281/121,499 | 0.52 (0.45–0.60) | 8.57E-19 | 0.60 (0.52–0.70) | 1.98E-11 | ||||
Abbreviations: PC Pancreatic cancer, PRS Polygenic risk score, HR Hazard ratio, NA Not applicable
aModel 1 was not adjusted; model 2 was adjusted for age (continuous), sex, education level, socioeconomic status, and the first 5 principal components of ancestry
bSet the intermediate value of PRS as the reference
c P value for trend was determined by using the categorical variables as continuous