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. 2023 Dec 1;120(49):e2310664120. doi: 10.1073/pnas.2310664120

Fig. 4.

Fig. 4.

Steric clash at the SAP05 loop 3 region prevents SAP05 binding to human and yeast vWA domains. The SAP05–AtRpn10vWA complex structure was aligned with the vWA domain structures of human Rpn10 (PSMD4, PDB 6MSD) and yeast (S. cerevisiae) Rpn10 (PDB5LN1) to compare their configurations. The dashed squared box on the top left shows the position of loop 3. Box on the top right, sequence alignment of vWA sequences from A. thaliana Rpn10 (Uniprot ID: P55034); HsRpn10, H. sapiens Rpn10 (Uniprot ID: Q5VWC4); ScRpn10, S. cerevisiae Rpn10 (Uniprot ID: P38886).