Fig. 1.

p53 REs belonging to genes in functional groups that are needed early in the response to stress are more deformable than REs belonging to genes needed later in the response to stress. Shown are functional groups with at least five genes each. All data points are shown as dots. The line across all groups marks the mean of means of the deformability of all analyzed groups. Center lines show the medians of each group. The figure was created by BoxPlotR (49). Box limits indicate the 25th and 75th percentiles, as determined by R software. Whiskers extend to maximum and minimum values. Boxes are arranged by decreasing group average values from left to right. Blue boxes denote the “flexible REs category,” and red boxes signify the “rigid REs category.” For significant differences between the groups, see SI Appendix, Table S2. DDR = DNA-damage response.