Fig. 2.
Sequence logos and information content of the studied REs. (A) All 210 p53 REs without spacers belonging to genes with the known functional outcome of p53 activation studied here. (B) REs belonging to the flexible REs category. (C) REs belonging to genes with intermediate flexible REs. (D) REs belonging to the rigid REs category. All included REs are those belonging to functional groups with at least five genes each, and the RE sequences were aligned by transcription direction before generating the sequence logos. Sequence logos were generated by Weblogo (57). (E) Information content per position (Iseql) on the mononucleotide level for the REs belonging to the flexible category (blue squares), rigid category (red circles), or REs with intermediate flexibility (green triangles).