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. 2023 Dec 8;11:20503121231216585. doi: 10.1177/20503121231216585

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Histology of kidney and liver in acute toxicity test: (a) normal controls received orally 10% Tween 20; (b) rats received orally low dose (250 mg/kg) of PN; and (c) rats ingested orally high dose (500 mg/kg) of PN (magnification, 20×). There were no significant changes in the structure of liver and kidney tissues between normal control and pinostrobin-treated rats. The kidney tissues showed normal glomeruli (yellow arrow) and a sufficient amount of blood vessels (blue arrow). The liver tissues revealed a clear central vein (green star), sinusoidal capillaries (grey arrow), Kupffer cell (black arrow) and normal hepatocytes with round nuclei (pink arrow) for all experimental rats.