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. Author manuscript; available in PMC: 2023 Dec 9.
Published in final edited form as: J Vis Exp. 2018 Nov 29;(141):10.3791/57849. doi: 10.3791/57849

Figure 2: Overview of the mastectomy model.

Figure 2:

(A) This panel shows a time course of the mastectomy model after 4T1 orthotopic syngeneic implantation. The scale bar indicates 1 cm. (B) This panel shows the whole-body bioluminescence of the mastectomy model, which mainly reflects metastatic lesion. The error bar indicates the standard error of the mean (n = 10). (C) This panel shows serial images of whole-body bioluminescence (of the same mouse). Utilizing ex vivo imaging, it was confirmed that the signals were from lung metastasis, and no local recurrence was confirmed by whole-body imaging after lung removal. Scale bar = 1 cm. (D) This panel shows the Kaplan-Meier survival curve of the mastectomy model without any drug treatment. Mice were euthanized when they reached euthanasia criteria with any morbid condition.