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. 2023 Dec 9;23:991. doi: 10.1186/s12903-023-03625-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Cocultured with THP-1 cells successfully enhanced IL-6 and IL-8 expressions. DPCs were cocultured with different ratios of THP-1 (A) or HL-60 (B) cells with 100 nM PMA and then extracted total RNA after 24 and 48 h. IL-6 and IL-8 mRNA expression were determined by RT-qPCR. A Both THP-1: DPCs = 1:10 and THP-1: DPCs = 1:1 increased IL-6 and IL-8 expression at 24 and 48 h. The data were expressed as the mean ± SD of triplicates from three independent experiments. *, p < 0.05; **, p < 0.005; ***, p < 0.0005 compared with THP-1: DPCs = 0:1 untreated control of each time point; ##, p < 0.005 compared with THP-1: DPCs = 1:10 of each time point; Δ, p < 0.05 compare with 24 h of each ratio group. Mann–Whitney test. B Both HL-60: DPCs = 1:10 and HL-60: DPCs = 1:1 increased IL-6 and IL-8 expression at 24 and 48 h. The data were expressed as the mean ± SD of triplicates from three independent experiments. *, p < 0.05; **, p < 0.005; ***, p < 0.0005 compared with HL-60: DPCs = 0:1 untreated control of each time point; ###, p < 0.0005 compared with HL-60: DPCs = 1:10 of each time point; Δ, p < 0.05; ΔΔΔ, p < 0.0005 compare with 24 h of each ratio group. Mann–Whitney test