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. 2023 Dec 6;16:5899–5913. doi: 10.2147/JIR.S439981

Figure 7.

Figure 7

Au inhibits chondrocyte pyroptosis in vivo and in vitro. (A and B) Representative immunohistochemical images of NLRP3 and Caspase-1 in the caudal L4-5 endplate at 4 weeks. Red arrows indicated positive expressions. Scale bar = 100 μm. (C and D) Quantitative analyses of the percent of NLRP3 and Caspase-1 positive cells in the endplates. The dose of Au was 10 mg/kg. (E) The protein expression of TNF-α-induced ATDC5 cell treated with various concentrations of Au for 24 h. (F and G) Quantitative analyses of the relative protein expression. Data were presented as means ± S.D. *p < 0.05; **p < 0.01; as compared to group treated with Vehicle in vivo or TNF-α in vitro (the second column), n ≥ 3 in each group.