Table 1. Insecticidal activities of 6-phenoxy quinoline derivatives against Plutella xylostella, Spodoptera litura, and Frankliniella occidentalis.

Compound No. (1st screening)	R1	R2	R3	R4	R5	EC90 (mg a.i./L)
						P. xylosotella	S. litura	F. occidentalis
cpd1 (Lead)	Me	Me	Cl	H	4′-Cl	100	>100	>200
cpd8	Et	Me	Cl	H	4′-Cl	5–20	>100	50–200
cpd9	n-Bu	Me	Cl	H	4′-Cl	>100	>100	>200
cpd10	Me	OMe	Cl	H	4′-Cl	10–20	>100	>200
cpd11	Me	t-Bu	Cl	H	4′-Cl	>100	>100	>200
cpd12	Me	Me	CF3	H	4′-Cl	<20	100	200
cpd13	Me	Me	CN	H	4′-Cl	>100	>100	>200
cpd14	Me	Me	Me	H	4′-Cl	20–100	>100	>200
cpd15	Me	Me	Cl	H	2′-Cl	100	>100	>200
cpd16	Me	Me	Cl	H	3′-Cl	20–100	>100	>200
cpd17	Me	Me	Cl	H	4′-CN	100	20–100	>200
cpd18	Me	Me	Cl	H	4′-Me	>100	>100	N.D.
cpd19	Me	Me	Cl	H	4′-F	100	>100	>200
cpd20	Me	Me	Cl	H	4′-CF3	20–100	20–100	<50
cpd21	Me	Me	Cl	H	4′-OMe	>100	>100	>200
cpd22	Me	Me	Cl	H	4′-OCF3	<20	100	<50
cpd23	Me	Me	CF3	H	4′-OCF3	1.25–2.5	2.5–5	20–50
cpd24	Me	Me	Me	H	4′-OCF3	20–100	20–100	100–200
cpd25	Me	Me	H	Me	4′-OCF3	2.5–5	20–100	100–200
cpd26	Me	Me	Me	Me	4′-OCF3	5–20	20–100	100
cpd27	Me	Me	Cl	Cl	4′-OCF3	>100	>100	20–100

N.D.: No Data, mg a.i./L: mg active ingredient/L