Table 6.

Posttranslational modification of Ferroptosis by SUMOylation in cancer

Cancer	Modification	Targets	Enzyme	Biological functions	Ref
Lung cancer	SUMOylation	A20	SENP1	Elevated SENP1 mediated A20 SUMOylation lead to decreased ACSL4 and increased SLC7A11, thereby inhibiting ferroptosis.	214
GBM	SUMOylation	ACSL4	GALNT14	Elevated HSP27 inhibit ferroptosis through inducing SUMOylation of ACSL4 to reduce its stability in GBM.	215

GBM glioblastoma, SENP1 Small ubiquitin-like modifier (SUMO)-specific protease 1