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. 2023 Nov 27;14:1245421. doi: 10.3389/fimmu.2023.1245421

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Copyright © 2023 Guha, Goswami, Sultana, Ganguly, Choudhury, Chakravarti, Bhuniya, Sarkar, Bera, Dhar, Das, Das, Baral, Bose and Banerjee

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The interaction between platelets and BCSCs. Representative image of the interaction between platelets and BCSCs. The interaction between platelets and BCSCs causes the release of transforming growth factor β1 (TGF-β1) from the α-granules of platelets. TGF-β1 inhibits NK cell activity by downregulating the expression of NKG2D which prevents the antitumor activity of NK cells.