Figure 2.

Properties of breast cancer stem cells (BCSCs). BCSCs show characteristics resembling those of typical stem cells. They are dormant cells that divide slowly. They have the capacity for self-renewal, thereby maintaining their population of undifferentiated cells. They divide asymmetrically to create daughter cells that undergo differentiation. This kind of cell division allows them to maintain their own pool while also producing the bulk of the tumor. They are immortal cells because they can withstand chemotherapy or radiation treatment. Following that, these therapy-resistant cells display all of EMT’s characteristics and a heightened ability for metastasis. They can grow in poor adherence cell culture plates under in-vitro conditions to form tumorspheres.