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. 2023 Nov 27;14:1245421. doi: 10.3389/fimmu.2023.1245421

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Copyright © 2023 Guha, Goswami, Sultana, Ganguly, Choudhury, Chakravarti, Bhuniya, Sarkar, Bera, Dhar, Das, Das, Baral, Bose and Banerjee

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The interaction between NK cells and BCSCs. Representative image of the interaction between NK cells and BCSCs. Upper panel: The NK cell interacts with the target cell via NKG2D. NKG2D interacts with its two ligands MICA and MICB on the surface of the target cell thereby mediating NK cell cytotoxicity. Lower panel: Interaction of NK cells with BCSCs causes reduction of MICA and MICB on the surface of BCSCs via miR20a. This prevents the functioning of NKG2D thereby preventing degranulation of NK cells and allowing BCSCs to escape NK cell-mediated cytotoxicity.