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. 2023 Nov 25;9(12):e22784. doi: 10.1016/j.heliyon.2023.e22784

Fig. 10.

Fig. 10

Nuclear translocation of REST and MECP2 after P. g LPS treatment is attenuated by siRage. The effects of Rage on the nuclear translocation of REST and MECP2 after LPS treatment were investigated. Immunostaining of REST (A–D), Immunostaining of MECP2 (E–H). LPS treatment induced the translocation of MECP2 and REST to the nucleus in PC-12 cells after transfection with the control si RNA (siN.C.) (A, B, E, F). Nuclear localization induced by LPS treatment was prevented when Rage was knocked down by siRNA treatment (C, D, G, H).